Structural dna nanotechnology derived from seemans innovative proposal that dna could be used as a physical material for the self assembly of nanoscale structures figure 1 has developed with astounding speed over the past 30 years. Structural dna nanotechnology was to use 3d dna lattices as hosts to organize guest protein molecules and facilitate protein crystallography although this vision has yet to be realized scientists have already begun to use dna nanostructures as chaperones to align and organize protein molecules using. Structural dna nanotechnology uses unusual dna motifs to build target shapes and arrangements these unusual motifs are generated by reciprocal exchange of dna backbones leading to branched systems with many strands and multiple helical domains the motifs may be combined by sticky ended cohesion involving hydrogen bonding or covalent interactions other forms of cohesion involve edge sharing or paranemic interactions of double helices a large number of individual species have been . Structural dna nanotechnology entails the use of branched dna molecules for the construction of novel materials on the nanometer scale the word structural in this context means that dna is used to produce specific geometrical motifs not merely complexes held together by smart glue
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